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. Author manuscript; available in PMC: 2009 Jan 23.
Published in final edited form as: Brain Res. 2007 Nov 19;1190:78–85. doi: 10.1016/j.brainres.2007.11.017

Figure 2. RGS9 KO Mice Exhibit Impaired Working Memory in the DMP Task of the Water Maze.

Figure 2

(A) RGS9 KO mice exhibited slower swim speeds than WT (RGS9 KO vs. WT, p > 0.05). (B) Block 1: RGS9 KO and WT showed no savings over the first 4 days (Days 1-4) of DMP training as measured by distance traveled to reach the submerged platform (RGS9 KO: Trial 1 vs. Trial 2, p = 0.28; WT: Trial 1 vs. Trial 2, p = 0.76). RGS9 KO mice traveled the same as WT to reach the platform during both Trial 1 and Trial 2 (Trial 1, p = 0.44; Trial 2; p = 0.98). (C) Block 2: RGS9 KO and WT did not exhibit savings over the second 4 days (Days 5-8) of DMP training (RGS9 KO: Trial 1 vs. Trial 2, p = 0.89; WT: Trial 1 vs. Trial 2, p = 0.77). RGS9 KO mice traveled the same as WT to reach the platform during both Trial 1 and Trial 2 (Trial 1, p = 0.33; Trial 2, p = 0.13). (D) Block 3: Similarly, RGS9 KO and WT did not exhibit savings over the third 4 days (Days 9-12) of DMP training (RGS9 KO: Trial 1 vs. Trial 2, p = 0.25; WT: Trial 1 vs. Trial 2, p = 0.17). RGS9 KO mice traveled the same as WT to reach the platform during both Trial 1 and Trial 2 (Trial 1, p = 0.23; Trial 2, p = 0.12). (E) Block 4: Unlike RGS9 KO mice, WT showed a savings in the final 4 days of testing in the DMP as measured by distance traveled to reach the platform (RGS9 KO: Trial 1 vs. Trial 2, p = 0.29; WT: Trial 1 vs. Trial 2, p < 0.05). RGS9 KO mice traveled the same distance as WT during Trial 1 (p = 0.40), but traveled more during Trial 2 (p = 0.0060).