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. Author manuscript; available in PMC: 2009 Jan 23.
Published in final edited form as: Brain Res. 2007 Nov 19;1190:78–85. doi: 10.1016/j.brainres.2007.11.017

Figure 3. RGS9 KO Mice are Impaired in the Visible Platform Task.

Figure 3

(A) RGS9 KO mice displayed an abnormal learning curve compared to WT during 12 trials as measured by latency to reach the visible platform in the water maze. ANOVA with repeated measures revealed a main effect of Genotype [F1,20 = 18.85, p = 0.00032], a main effect of Trial [F11,220 = 2.27, p = 0.012] but no interaction between Genotype and Trial [F11,220 = 0.55, p = 0.87]. However, there was no difference between RGS9 KO and WT in duration to the platform on trial 12 (p > 0.05). Legend in A applies to Panels A-C. (B) Swim speed was unaffected by genotype (F1,11 = 0.82, p = 0.38). (C) Similar to A, RGS9 KO mice displayed an abnormal learning curve compared to WT during 12 trials as measured by distance traveled to reach the visible platform in the water maze. ANOVA with repeated measures revealed a main effect of Genotype [F1,20 = 14.42, p = 0.0011], a main effect of Trial [F11,220 = 2.07, p = 0.023] but no interaction between Genotype and Trial [F11,220 = 0.53, p = 0.88]. However, there was no difference between RGS9 KO and WT in distance traveled during trial 12 (p>0.05).