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. Author manuscript; available in PMC: 2008 Feb 13.
Published in final edited form as: J Dent Res. 2005 Apr;84(4):320–323. doi: 10.1177/154405910508400405

Figure 3.

Figure 3

Enhanced accumulation of tetracyclines by PMA-activated fibroblasts. Confluent fibroblast cultures were starved for 20 hrs and treated with 3 to 100 nM PMA for 15 min prior to assaying transport of minocycline, doxycycline, and tetracycline. The data represent the mean ± SEM of 6 individual experiments. PMA produced a significant treatment effect on the accumulation of all 3 agents (P ≤ 0.002, repeated-measures ANOVA). PMA concentrations indicated by * induced a significant increase in antibiotic accumulation (P > 0.05, Dunnett’s test).