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Membrane depolarization induces an attenuated [Ca2+]i elevation and constriction in cav-1−/− arteries. Mean arterial wall [Ca2+]i (A) and constriction (B) induced by 60 mM K+ in pressurized (70 mmHg) cav-1+/+ (n = 8) and cav-1−/− (n = 6) cerebral arteries. *P < 0.05 when compared with cav-1+/+ arteries.
