Table 1.
Comparison* of MR indices between lesions and normal appearing white matter (NAWM) in brain samples of patients with MS before and after fixation. Mean= mean of individual patient means (averaged across tissue sample), SD= standard deviation of these individual patient means, MTR= magnetisation transfer ratio, fB= macromolecular proton fraction, MD= mean diffusivity, Dax= axial diffusivity, Drad= radial diffusivity [mm2s−1× 10−3], FA= fractional anisotropy.
| Lesions | NAWM | |||
|---|---|---|---|---|
| Index | Condition | N cases | Mean (SD) | Mean (SD) |
| T1 [ms] | Unfixed | 15 | 1207 (294) | 681 (137) |
| Fixed | 14 | 748 (154) | 377 (73) | |
| T2 [ms] | Unfixed | 15 | 121 (13) | 81 (8) |
| Fixed | 15 | 107 (12) | 61 (5) | |
| MTR [pu] | Unfixed | 15 | 24.5 (2.3) | 33.9 (2.8) |
| Fixed | 15 | 22.5 (3.8) | 30.0 (3.7) | |
| fB [pu] | Unfixed | 10 | 3.1 (1.3) | 7.0 (2.1) |
| Fixed | 12 | 4.6 (1.5) | 10.7 (2.6) | |
| MD | Unfixed | 13 | 0.36 (0.09) | 0.22 (0.47) |
| Fixed | 15 | 0.31 (0.08) | 0.16 (0.04) | |
| Dax | Unfixed | 13 | 0.43 (0.12) | 0.29 (0.05) |
| Fixed | 15 | 0.34 (0.08) | 0.20 (0.04) | |
| Drad | Unfixed | 13 | 0.34 (0.1) | 0.2 (0.05) |
| Fixed | 15 | 0.29 (0.08) | 0.15 (0.05) | |
| FA | Unfixed | 13 | 0.23 (0.06) | 0.40 (0.14) |
| Fixed | 15 | 0.19 (0.05) | 0.39 (0.12) | |
*
All differences p≤0.01