Table 3.
Comparison of biochemical data of the low HDL-C and control subjects between different groups of G1522A genotypes.
| Control subjects | t test p * | Low HDL-C subjects | t test p * | |||
| GG | AG + AA | GG | AG + AA | |||
| n | 129 | 101 | 75 | 42 | ||
| Age (y) | 50 ± 10 | 50 ± 8 | 0.5 | 49 ± 9 | 51 ± 11 | 0.4 |
| Gender (M/F) | 81/48 | 69/32 | 0.3 | 52/23 | 32/10 | 0.4 |
| BMI (kg/m2) | 26.4 ± 4.6 | 26.3 ± 4.4 | 0.9 | 28.3 ± 5.2 | 27.7 ± 4.5 | 0.5 |
| DM (%) | 10.5 | 10.9 | 0.9 | 20.3 | 19.0 | 0.9 |
| HTN (%) | 19.3 | 22.8 | 0.5 | 51.3 | 33.3 | 0.06 |
| CAD (%) | 45.9 | 56.0 | 0.1 | 75.4 | 65.8 | 0.3 |
| FH of CAD (%) | 51.7 | 75.8 | 0.0003 | 75.0 | 67.5 | 0.4 |
| TG (mmol/L) | 1.60 ± 0.89 | 1.70 ± 0.89 | 0.4 | 4.34 ± 3.89 | 3.19 ± 1.90 | 0.07 |
| T Chol (mmol/L) | 5.55 ± 1.19 | 5.96 ± 1.62 | 0.03 | 6.33 ± 2.39 | 5.25 ± 1.56 | 0.009 |
| HDL-C (mmol/L) | 1.34 ± 0.31 | 1.33 ± 0.33 | 0.8 | 0.67 ± 0.13 | 0.67 ± 0.13 | 0.9 |
| LDL-C (mmol/L) | 3.51 ± 1.10 | 3.93 ± 1.54 | 0.02 | 3.71 ± 1.74 | 3.17 ± 1.34 | 0.09 |
BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; CAD, coronary artery disease; FH, familial history; TG, plasma triglycerides; T Chol, total plasma cholesterol; HDL-C, plasma high-density lipoprotein cholesterol; LDL-C, plasma low-density cholesterol.
* significant p-value bolded.