Table 5.
Comparison of biochemical data of the low HDL-C and control subjects between the most prevalent genotypes of the hexanucleotide repeat polymorphism in the SMPD1 gene.
| Control subjects (n = 230) | t test p | Low HDL-C subjects (n = 118) | t test p* | |||||
| 6/6 | 6/7 | 7/7 | 6/6 | 6/7 | 7/7 | |||
| n | 45 | 101 | 45 | 29 | 43 | 30 | ||
| Age (y) | 50 ± 8 | 50 ± 9 | 49 ± 9 | 0.79 | 48 ± 10 | 51 ± 10 | 49 ± 10 | 0.51 |
| Gender (M/F) | 30/15 | 68/33 | 29/16 | 0.94 | 22/7 | 29/14 | 20/10 | 0.69 |
| BMI (kg/m2) | 26.1 ± 5.1 | 26.4 ± 4.0 | 26.0 ± 4.1 | 0.86 | 27.9 ± 4.2 | 27.8 ± 5.1 | 29.2 ± 5.6 | 0.45 |
| DM (%) | 15.0 | 55.0 | 30.0 | 0.57 | 19.0 | 42.9 | 38.1 | 0.47 |
| HTN (%) | 23.1 | 61.5 | 15.4 | 0.35 | 22.2 | 35.6 | 42.2† | 0.04 |
| CAD (%) | 26.1 | 51.1 | 22.8 | 0.77 | 23.9 | 45.1 | 31.0 | 0.16 |
| FH of CAD (%) | 28.3 | 53.3 | 18.3 | 0.05 | 23.6 | 43.1 | 33.3 | 0.15 |
| TG (mmol/L) | 1.60 ± 0.68 | 1.56 ± 0.85 | 1.68 ± 0.88 | 0.71 | 2.73 ± 1.38 | 4.94 ± 3.65† | 3.57 ± 2.58 | 0.005 |
| T Chol (mmol/L) | 6.09 ± 1.45 | 5.61 ± 1.52 | 5.82 ± 1.32 | 0.19 | 5.56 ± 2.21 | 6.12 ± 1.77 | 6.03 ± 2.06 | 0.48 |
| HDL-C (mmol/L) | 1.36 ± 0.34 | 1.33 ± 0.31 | 1.31 ± 0.28 | 0.80 | 0.66 ± 0.11 | 0.67 ± 0.13 | 0.69 ± 0.10 | 0.55 |
| LDL-C (mmol/L) | 3.96 ± 1.37 | 3.60 ± 1.34 | 3.79 ± 1.39 | 0.32 | 3.60 ± 2.08 | 3.38 ± 1.34 | 3.68 ± 1.62 | 0.74 |
BMI, body mass index; DM, diabetes mellitus; HTN, hypertension; CAD, coronary artery disease; FH, familial history; TG, plasma triglycerides; T Chol, plasma cholesterol; HDL-C, plasma high-density lipoprotein cholesterol; LDL-C, plasma low density lipoprotein cholesterol.
†significantly different from genotype 6/6.
* significant p value bolded.