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. 2007 Nov 26;153(3):497–507. doi: 10.1038/sj.bjp.0707600

Figure 3.

Figure 3

Relaxations of porcine coronary arteries to NTG (left panel) and DETA NONOate (right panel) following 24 h incubation with the respective nitrovasodilators plus NAC (10−2 M). Vessels were constricted with U46619 (10−7 to 3 × 10−7 M) before testing their relaxant responses. Data are shown as means±s.e.mean; n=6–8 for each group. *Significant difference between vessels incubated with NAC and those with NTG at 10−6 M plus NAC (left panel) or between vessels incubated with NAC and DETA NONOate at 10−5 M plus NAC (right panel) (P<0.05); †significantly different from vessels incubated with NTG at 10−6 M plus NAC (left panel) (P<0.05). DETA NONOate, [2,2′-(hydroxynitrosohydrazono) bis(ethanamine)]; NTG, nitroglycerine; NAC, N-acetyl-L-cysteine; U46619, (9,11)-dideoxy-(11α,9α)-epoxymethanoprostaglandin F2α.