Figure 4.

Inability of indomethacin and aspirin to enhance eosinophil production in bone marrow from cys-LT1 receptor- or LTC₄ synthase-deficient mice. The data are mean±s.e.mean of the number of EPO+ cells in liquid cultures established from bone marrow of control (Wild Type) or mutant (cys-LT1R−/− (a and b); LTC4s−/− (c)) mice from the BALB/c (a and c) or the C57BL/6 strains (b), in the presence of IL-5 alone, or associated with the following: LTD₄, indomethacin or aspirin, at the indicated molar concentrations (10⁻⁷ M in (c)). Data are derived from 3 to 4 experiments. ^*P<0.01 relative to the IL-5 control. cys-LT, cysteinyl-leukotriene; EPO, eosinophil peroxidase; IL, interleukin.