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. 2007 Nov 26;153(3):517–527. doi: 10.1038/sj.bjp.0707573

Figure 5.

Figure 5

Characterization of apamin-resistant biphasic and monophasic IJPs in LES clasp (A) and sling (B) muscles before (a) and 10 min after (b) application of L-NAME (200 μM), an NOS inhibitor. Experiments were performed in the presence of atropine, apamin, guanethidine and substance P. (c) Superimposed IJPs before and 10 min after L-NAME. L-NAME inhibited IJP amplitude in sling muscle by about 90%, while it decreased the amplitude of the initial phase of the biphasic IJP by 60% and abolished the long-lasting slow IJP in clasp muscle, suggesting that nitric oxide mediates the apamin-resistant IJP and the biphasic IJP in both sides of the LOS. IJP, inhibitory junction potential; LOS, lower oesophageal sphincter; L-NAME, N-nitro-L-arginine methyl ester.