Skip to main content
. 2007 Nov 26;153(3):517–527. doi: 10.1038/sj.bjp.0707573

Figure 6.

Figure 6

Properties of the IJP recorded in clasp muscle of nNOS(−/−) mouse in the presence of atropine, guanethidine and substance P. (A) Recording of membrane potentials. (B) IJPs depicted in (A) at expanded time scale. Only a monophasic IJP (B(a)) was recorded, which was essentially abolished by apamin (300 nM, 10 min) (B(b)). Further application of L-NAME (200 μM, 10 min) did not have any significant effect (B(c) and (d)). The finding of only an apamin-sensitive IJP in nNOS(−/−) mice suggests that nitrergic innervation mediates a component of the initial IJP and all of the long-lasting slow IJP in clasp muscle. IJP, inhibitory junction potential; L-NAME, N-nitro-L-arginine methyl ester.