Table 2.

Pharmacological properties of IJPs in LOS clasp of nNOS knockout mice

	RMP (mV)	IJP amplitude (mV)	IJP duration (ms)
Control n=4	−41.0±3.3	6.6±1.5	366±61
Apamin (300 nM)	−38.4±3.0	2.4±0.5*	518±97
Apamin (300 nM)+ L-NAME (200 μM)	−35.0±3.9	1.8±0.4	N/M

Abbreviations: LES, lower oesophageal sphincter; L-NAME, N-nitro-L-arginine methyl ester; N/M, not measured or not measurable; RMP, resting membrane potential.

*P<0.05 before and after drug application.

‘Control' represents results obtained in the presence of atropine (3 μM), guanethidine (3 μM) and substance P (1 μM).