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Effect of 7-nitroindazole or aminoguanidine on phenylephrine-induced contraction of female rat aortic rings. Concentration–response curves for phenylephrine were determined in endothelium-intact aortic rings from control and ethanol-treated rats. The curves were determined in the absence (control) or after 30-min incubation with 7-nitroindazole (100 μmol l−1) or aminoguanidine (100 μmol l−1). *Compared to respective control group (P<0.05; Student's t-test).
