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Expression of L22P in MEFs sensitizes them to MMS. (A) Western blot. Lane 1, negative control; lane 2, cells with pRVY-Tet expressing WT pol β and lane 3, cells with pRVY-Tet expressing L22P. The blot was probed with monoclonal antibody to pol β as described (15). (B) Survival curves. (Open triangle), pol β-deleted MEFs; (filled square), MEFs expressing WT pol β; (outlined triangle) MEFs expressing L22P pol β.
