Figure 1.

Mutational specificity of DNA polymerases in the [T]₁₁ assay. Middle sequence is the microsatellite target. Base substitutions are indicated above the sequence and frameshifts are indicated below. Symbols: open triangle: one T deletion (paired with a large 28bp coding region deletion); filled triangle: one T insertion (paired with a C to T at 100 or a C to T at 130); open diamond: two T deletion; letter ‘v’: insertion of noncanonical base. Subscripts indicate multiple errors detected within a single mutant. 1, T insertion paired with G to T at 110; 2, T deletion paired with T to C at STR; 3, T deletion paired with C 109 deletion; 4, T insertion paired with G insertion.