Scheme 1.
Strategy for regulating mRNA (blue strand) digestion by RNase H (green surface rendering) using a photoactive asODN conjugate (red and magenta strands). Oligonucleotide structures were generated with Insight II (Accelrys, San Diego, USA). Representation of RNase H was generated from the PDB coordinates using PyMol (DeLano, W.L., 2002, on World Wide Web, http://www.pymol.org).