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. 2007 Dec 26;36(3):1050–1056. doi: 10.1093/nar/gkm1136

Figure 1.

Figure 1.

Somatic instability in ATR+/− mice carrying an FXS premutation allele. Genomic DNA was isolated from various organs of young (10 weeks old) and old (18 months old) FXS premutation mice and the repeat tract analysed by PCR using one FAM-labelled primer and an ABI GeneAnalyzer as described in the Materials and Methods. The number repeats in the modal allele in the tail DNA at 3 weeks of age is shown in black font and is indicated in the other organ samples by the grey dotted line. Similar results were obtained using PCR using 32P-α-dCTP and denaturing gel electrophoresis as described previously (49).