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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Gen Comp Endocrinol. 2007 Apr 27;155(1):201–207. doi: 10.1016/j.ygcen.2007.04.013

Figure 2. Partial amino acid alignment of human (Hs) IGFBP-3 and a novel zebrafish (Dr) tankyrase homolog (TANK1).

Figure 2

BLASTP analysis of the zebrafish EST database using a 150 amino acid sequence from the amino terminus of human IGFBP-3 identified a novel tankyrase homolog (GenBank: XM_682318.1, GI:68397005) that shares motifs common to the IGFBPs and IGFBP-rPs. Alignment positions are numbered above the sequences whereas residue numbers within a specific sequence are indicated to the left and in parentheses. Conserved regions are shaded and residues necessary for IGF-binding (Buckway et al., 2001; Yan et al., 2004) are indicated with asterisks.