Figure 3.

Examples of aqueous proteins with unusually long hydrophobic blocks. Images show cartoons of three representative protein structures, with long hydrophobic blocks highlighted in red. (A) Cytidine deaminase, an example of a protein with a hydrophobic block occurring as a partially buried helix; (B) 7,8 diaminopelargonic acid synthase, an example of a protein with a hydrophobic block occurring as a buried strand and turn region; (C) phage PRD1 receptor binding protein P2, illustrating an unusual surface-exposed example of a long hydrophobic block. Prolines in the P2 block are highlighted.