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. Author manuscript; available in PMC: 2009 Jan 1.
Published in final edited form as: Neuropharmacology. 2007 Jul 1;54(1):117–128. doi: 10.1016/j.neuropharm.2007.06.023

Figure 4. CCK-induced sIPSPs are generated by interneurons that depend on P/Q- and not N-type Ca2+ channels for GABA release.

Figure 4

Agatoxin (AgTx) prevents occurrence of CCK-sIPSPs, but not occurrence of CCh-sIPSPs. A) Pre-treatment of a slice for 60 min with 1 μM ω-agatoxin prevents CCK8-S from inducing sIPSPs. B1) Agatoxin does not prevent induction of sIPSPs by CCh. Subsequent CCK8-S application does not reduce the CCh-sIPSPs in agatoxin. Calib. = 5 mV, 1 sec in A and B. B2) Group data (n=7) showing that agatoxin blocks the CCK reduction of CCh-sIPSPs. C1) Slices were pretreated for 60 min with 250 nM conotoxin, which was also present in the bath solution. Conotoxin does not prevent CCK8-S from inducing sIPSPs, but prevents large CCh-sIPSPs. Calib. 5 mV, 2 sec. C2) Group data (n=4) showing effects of conotoxin.