Scheme 1.
DBD folding mechanism (left) and schematic representation of fast and slow-folding channels (right). The fast and slow channels are the upper and lower pathways, respectively, on the left, and are colored black and gray on the right. Folding tracks are depicted in the right panel as follows: track a, solid black line; track b, solid black and dashed black lines; track c, gray line. Track d is not shown. Microscopic rate constants that quantitatively reproduce kobs, a, kobs, b, and kobs, c and their associated amplitudes at 10°C are as follows (in units of sec−1): kU1 = 200, k1U = 30, k12 = 1, k21 = 0.001, k13 = 0.4, k31 = 0.01, k24 = 0.04, k42 = 0.02, k35 = 0.1, k53 = 0.02, k2N = 0.08, kN2 = 12×10−5, k36 = 0.001, k63 = 82×10−7, k6N = 0.3, kN6 = 0.005.