Table 1.

The 14 changes between 4-4-20 and 4M5.3

Residue (4-4-20)	Chain number	Residue (4M5.3)	Location
Phe	L60	Val	CDR2
Ser	L81	Asn	FR3
Asp	H1	Gly	FR1
Arg	H16	Gly	FR1
Pro	H17	Ala	FR1
Ala	H24	Thr	FR1
Ser	H30	Gly	FR1
Asp	H31	His	CDR1
Ile	H51	Phe	CDR2
Met	H93	Thr	FR3
Ser	H101	Ala	CDR3
Tyr	H102	Ser	CDR3
Asp	H106	Glu	CDR3
Trp	H108	Leu	FR4

The “Min7” mutations are bold; CDR: Complementarity determining region; FR: Framework region.