Table 3.

Partial mutant combinations

Mutant set	Mutations in 4-4-20
Contact	D(H31)H, S(H101)A, Y(H102)S
Noncontact	V(L60)F, I(H51)F, D(H106)E, W(H108)L
CDR3	S(H101)A, Y(H102)S, D(H106)E
Non-CDR3	V(L60)F, D(H31)H, I(H51)F, W(H108)L
CDR3+108	S(H101)A, Y(H102)S, D(H106)E, W(H108)L
Non-(CDR3 + 108)	V(L60)F, D(H31)H, I(H51)F
Early	I(H51)F, W(H108)L
Late	V(L60)F,D(H31)H,S(H101)A,Y(H102)S,D(H106)E