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Pressure dependence of the microscopic folding (kf) and unfolding (ku) rate constants for the wild-type enzyme and variants. Microscopic rate constants were determined as indicated in Materials and Methods according to Equations 4 and 5. (•) Wild-type enzyme, (×) Val47Ala, (▴) Val54Ala, (Δ) Val57Ala, (▴) Ile81Ala, (□) Ile106Ala, (○) Ile107Ala, and (♦) Val108Ala.
