Table 2.

 Effect of compounds on insulin aggregation

^aThe compound was added to insulin at the indicated concentration prior to initiation of aggregation. The putative recognition domain is indicated in bold.

^bKinetics were assayed using ThT fluorescence. The lag time was calculated as the midpoint between measurements where the ThT fluorescence increased from near baseline value to at least threefold greater than baseline. The change in lag time is the difference between the measured lag time and that for insulin alone (∼50 h). Values are an average of data obtained from multiple experiments. Representative kinetic data are shown in Figures 1, 3, and 6.