Figure 2.
MtAK–substrate interactions. Panel A shows a close view of the substrate-binding cleft. The 2Fo − Fc electron density map at 1.9 Å resolution (contoured at 1 σ) is shown for the nucleotide substrates and the cofactor Mg2+ (green sphere). Water molecules are drawn as red spheres. Panel B shows a schematic representation of enzyme–substrate hydrogen bonding interactions (dashed lines), with the interatomic distances given in angstroms.