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Proteins with similar topology but poor accuracy. In each case, the native structure is on the left, and the structure with lowest RMSD from the largest cluster is on the right, labeled with its RMSD. For the two helical proteins, hydrogen bonds alone are insufficient to select the correct helix orientation; long-range hydrophobic interactions are probably required. The two larger proteins have more complicated topologies and may also suffer from omission of long-range interactions.
