Figure 5.
Water and the connectivity of protein–protein interfaces. (A) Chymotrypsin-eglin (1acb). The facets belong to the AB interface and form a single scc. In the ABW model, the interface is split into two scc marked by the heavy lines. Water is located around the interface and in the gap separating the two scc. (B) The transducin Gα–Gβγ interface (1got). The interface is in two parts, each lined by water molecules. They form a single scc in the AB model and two in the ABW model. In both 1acb and 1got, the two scc of the ABW model merge into one due to connecting waters.