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Retroviral gene traps have the potential to (A) ablate miRNA transcription or (B) lead to constitutive overexpression of the miRNA.
(C) Schematic of a recombinant gene-targeting strategy whereby an intronic miRNA is ablated or (D) the miRNA is upstream and/or downstream of the targeting cassette. Promoter, green; exon, blue; selection marker, white; splice acceptor or donor, yellow; transcriptional terminator, red.
