FIG. 5. Enzyme-linked immuno sorbent assay.
Protein S was bound to the micro-titre plate through the non-calcium dependent monoclonal antibody HPS56. Peroxidase-conjugated HPS 54, a calcium dependent monoclonal antibody directed against EGF1, was used as a marker. ■ indicates wild-type protein S and ▲ indicates protein S with mutation Asn217Ser. All experiments were performed with 1 mM EDTA in the assay, and the shown concentrations of calcium are the concentrations calculated not to be bound to EDTA.