Figure 2.

Structure-based sequence alignment of hOSF-SH3 with the most similar SH3 domains. The sequence numbers for the first and the last residues are indicated. The positions of the β-strands in hOSF-SH3 are indicated by underlining the sequence and are labeled. Residues that are highly conserved in the SH3-domain family are indicated in bold type. Residues that are known to form the proline-rich ligand-binding pocket are marked with an asterisk. See Table 2 ▶ for protein PDB codes and references.