Figure 7.

(A) AcCho-current mediated by α₁β₁δ AcChoRs. The oocyte was held at a membrane potential of −60 mV, with 20 mV steps from −140 to 40 mV, in normal Ringer solution during AcCho application and during coapplication with 10 μM strychnine. (B) Comparison between the current elicited by AcCho alone and that in the presence of 10 μM strychnine, in a logarithmic scale, as a function of membrane potential, on oocytes expressing α₁β₁γδ (filled squares), α₁β₁γ (open circles), or α₁β₁δ (filled circles) AcChoRs. The continuous lines are the fits to one-site blocking model (see text).