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Effect of the V715M-βAPP mutation on the secretion of total Aβ by cultured neurons. TSM1 neuronal cells were obtained (10), cultured, and transiently transfected with wt-, Sw-, or V715M-βAPP as described in Experimental Procedures. βAPP content was analyzed after Western blotting by means of mAbWO2 (A). Total secreted Aβ was analyzed after immunoprecipitation with FCA18 and Western blot analysis of immunoprecipitated proteins with mAbWO2 as described in Experimental Procedures (B).
