Table 2. Multivariate analysis of overall, unique and nonunique mutations in D7S1482.

	Surgery only/controls (N=41)	Controls only (N=31)	All subjects (N=56)
Overall mutations
Agea	1.267, (0.991–1.618); 0.067	1.343 (1.117–1.614); 0.004	1.340 (1.054–1.702); 0.021
Pack-yearb	0.968 (0.969–1.079); 0.561	0.959 (0.865–1.064); 0.441	0.990 (0.901–1.066); 0.636
Case statusc	2.074 (1.174–3.665); 0.017	N/A	1.609 (0.917–2.823); 0.104
Unique mutations
Agea	1.163 (1.016–1.331); 0.035	1.181 (1.019–1.369); 0.036	1.240 (1.097–1.401); 0.002
Pack-yearb	0.987 (0.929–1.048); 0.666	0.978 (0.905–1.058); 0.585	0.989 (0.945–1.034); 0.624
Case status	1.183 (0.834–1.678); 0.352	N/A	1.116–0.835–1.493); 0.462
Nonunique mutations
Agea	1.325 (0.962–1.824); 0.093	1.449 (1.154–1.819); 0.035	1.394 (1.015–1.913); 0.045
Pack-yearb	0.960 (0.835–1.103); 0.567	0.948 (0.830–1.084); 0.443	0.975 (0.875–1.087); 0.654
Case status	2.645 (1.290–5.423); 0.012	N/A	1.924 (0.915–4.048); 0.091

^aRate ratio for 10-year age interval (95% confidence interval); P-value GLM.

^bRate ratio for 10-pack-year interval (95% confidence interval); P-value GLM.

^cRate ratio for case status (95% confidence interval); P-value GLM.

Statistically significant values are indicated in bold.