Table 3. Ethnic-specific, core covariate-adjusteda multiple linear regression analysis for the association between measurements of haematopoietic stem cell populations and birth weight.
|
Birth weight (g) in categories
|
Birth weight per 500 g | |||||
|---|---|---|---|---|---|---|
| Ethnicity | Stem cell measurements | <3000 % Difference (95% CI) | 3000–3499 Reference (geometric meanb) | 3500–3999 % Difference (95% CI) | ⩾4000 % Difference (95% CI) | % Difference (95% CI) |
| Both parents Caucasian | CD34+ | −13.9 (−37.2, 18.0) | 0.0 (7.73) | 8.3 (−15.2, 38.3) | 37.5 (−11.2, 113.1) | 16.6 (0.9, 34.7) |
| CD34+CD38− | −18.0 (−43.0, 17.9) | 0.0 (3.41) | 14.3 (−13.7, 51.4) | 80.5 (9.1, 198.7) | 23.8 (4.7, 46.4) | |
| CD34+c-kit+ | −11.5 (−40.8, 32.3) | 0.0 (6.44) | 18.4 (−11.0, 57.5) | 63.4 (−1.0, 169.5) | 22.9 (3.6, 45.8) | |
| CFU-GM | 19.3 (−25.9, 92.8) | 0.0 (4.01) | 36.9 (−3.4, 94.1) | 40.0 (−25.3, 162.5) | 19.7 (−3.3, 48.2) | |
| Either parent non-Caucasian | CD34+ | 28.4(−12.1, 87.6) | 0.0 (6.47) | 19.9 (−16.6, 72.3) | −0.6 (−46.6, 85.3) | 0.5 (−18.1, 23.5) |
| CD34+CD38− | 23.2 (−16.2, 81.2) | 0.0 (2.84) | 28.2 (−10.8, 84.4) | 13.5 (−39.1, 111.7) | 6.3 (−13.8, 31.0) | |
| CD34+c-kit+ | 42.1 (−6.2, 115.5) | 0.0 (5.39) | 22.2 (−17.2, 80.4) | 9.2 (−43.9, 112.6) | −0.4 (−20.4, 24.7) | |
| CFU-GM | 68.4 (14.0, 148.6) | 0.0 (4.08) | 21.0 (−18.1, 78.6) | 24.3 (−37.5, 147.1) | −7.3 (−26.0, 16.1) | |
a
Core covariates included mother's age, parity, gestation duration, gender of baby (male or female), delivery time (night or day) and study site (ACBP or T-NEMC).
b
Unadjusted geometric means. The unit for the stem cell measurements was per 1000 MNC. Statistical significance of P<0.05 are given in bold.