Figure 5.

rCBF by laser-Doppler flowmetry during MCA occlusion in Tg and WT mice. Similarity in the relative changes in rCBF after MCA occlusion in Tg and WT mice in brain regions in the peri-infarct zone (penumbra) and the MCA core territory were shown. The rCBF level was determined simultaneously in the two regions by laser-Doppler flowmetry in six animals from Tg and WT. Time zero represents the point of MCA occlusion. Modest decreases was shown in the peri-infarct zone in both groups. More severe reduction in rCBF was present in a more deeply ischemic territory; no differences were detected between the two groups.