Table 4.
Geometric Mean Serum Hemagglutination-Inhibiting (HAI) and Neutralizing (Neut) Antibody Titers Before (Pre) and After (Post) Immunization1
| H13 |
H33 |
B3 |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HAI | Neut | HAI | Neut | HAI | Neut | ||||||||
| Group & Dosage2 |
No. |
Pre |
Post |
Pre |
Post |
Pre |
Post |
Pre |
Post |
Pre |
Post |
Pre |
Post |
| Total Group | |||||||||||||
| Standard | 208 | 11.0 | 21.1 | 14.1 | 27.5 | 58.9 | 97.1 | 28.9 | 47.8 | 15.74 | 25.6 | 66.84 | 132.6 |
| High | 206 | 9.7 | 36.0 | 12.8 | 39.7 | 50.2 | 137.8 | 23.3 | 65.9 | 12.8 | 31.1 | 44.4 | 127.6 |
| Prev Vaccine | |||||||||||||
| Standard | 162 | 12.3 | 20.3 | 16.1 | 26.5 | 67.4 | 99.9 | 33.4 | 48.0 | 18.2 | 24.5 | 86.4 | 129.1 |
| High | 159 | 11.1 | 31.9 | 14.4 | 35.5 | 54.9 | 115.8 | 25.1 | 55.5 | 14.7 | 29.3 | 54.9 | 114.8 |
| No Prev Vaccine | |||||||||||||
| Standard | 46 | 7.4 | 24.0 | 8.9 | 31.8 | 36.7 | 87.8 | 17.4 | 47.4 | 9.4 | 29.7 | 27.1 | 145.5 |
| High | 47 | 6.1 | 54.4 | 8.7 | 58.2 | 37.1 | 248.6 | 18.3 | 117.2 | 7.9 | 37.6 | 21.7 | 182.4 |
1
GMT increase from pre to post is significant (p = <.0001) for each comparison
2
Prev vaccine = previously vaccinated (2 to 5 months earlier); no prev vac = no previous vaccine; standard dosage = 15 µg of each component, high dosage = 60 µg of each component
3
H1 = A/New Caledonia (H1N1), H3 = A/Wyoming (H3N2) for HAI, and A/Fuijan (H3N2) for neut, B = B/Jilin
4
Significantly higher than for high dosage
Note: High dose statistically significantly greater for all dose comparisons except for B neut in not previously vaccinated (see text)