Table 5.
Proportion (%) of Subjects with Hemagglutination-Inhibition (HAI) Titers After Immunization of ≥32, 64, and 128
H12 |
H32 |
B2 |
||||||||
---|---|---|---|---|---|---|---|---|---|---|
Group & Dosage1 |
No. |
≥32 |
≥64 |
≥128 |
≥32 |
≥64 |
≥128 |
≥32 |
≥64 |
≥128 |
Total Group | ||||||||||
Standard | 208 | 48.1 | 21.2 | 8.7 | 91.8 | 71.6 | 49.0 | 57.2 | 24.0 | 8.2 |
High | 206 | 62.6* | 41.7* | 19.4* | 94.7 | 84.5* | 57.3 | 62.1 | 35.9* | 12.6 |
Prev Vaccine | ||||||||||
Standard | 162 | 46.3 | 20.4 | 8.0 | 92.6 | 72.8 | 49.4 | 54.9 | 22.2 | 6.8 |
High | 159 | 59.1* | 37.1* | 15.1* | 93.1 | 81.8 | 52.2 | 60.4 | 32.1* | 10.1 |
No Prev Vaccine | ||||||||||
Standard | 46 | 54.3 | 23.9 | 10.9 | 89.1 | 67.4 | 47.8 | 65.2 | 30.4 | 13.0 |
High | 47 | 74.5* | 57.4* | 34.0* | 100.0* | 93.6* | 74.5* | 68.1 | 48.9 | 21.3 |
Prev vaccine = previously vaccinated (2 to 5 months earlier); no prev vac = no previous vaccine; standard dosage = 15 µg HA of each component; high dosage = 60 µg HA of each component
H1 = A/New Caledonia (H1N1), H3 = A/Wyoming (H3N2) for HAI, and A/Fujian (H3N2) for neut, B = B/Jilin
High dose statistically significantly greater than standard dose (see text)