TABLE.

Involvement of TLR2 in the progression of atherosclerotic plaque formation

		aorta plaque area (mm2)
		5 month	7 month	interaction
Male	Apoe−/−	1.32 ± 0.55	6.20 ± 3.05*	P = 0.0046
	Tlr2−/−Apoe−/−	0.55 ± 0.51	1.89 ± 0.84*†
		(58.4%)	(69.5%)
Female	Apoe−/−	3.10 ± 1.51	13.05 ± 4.62*	P = 0.0017
	Tlr2−/−Apoe−/−	1.59 ± 0.85	4.56 ± 2.84*†
		(51.34%)	(65.1%)

Interaction; interaction between genotype and age.

Statistical analysis was performed by Two-way ANOVA.

^*P<0.001 significant between 5 and 7-month old mice with same genotype.

^†P<0.001 significant between Apoe^−/− and Tlr2^−/−Apoe^−/− mice with same age.

(); reduction of % ratio in Tlr2^−/−/Apoe^−/− against Apoe^−/− mice.