Table 2.

Hyperglycemic clamp data (mean ± sd)

Outcome	Control day	Estradiol day	P value
E2 (pg/ml)
Baseline	19 ± 5	249 ± 142	<0.001
End stage	16 ± 4	288 ± 157	<0.001
Glucose (mg/dl)
Baseline	98 ± 8	93 ± 6	0.004
End stage	250 ± 9	257 ± 9	0.158
INSAUC (μU/ml × min)
End stage	11,806 ± 6,754	11,226 ± 5,395	0.719
CPEPAUC (ng/ml × min)
End stage	787 ± 138	798 ± 214	0.807
C-peptide to insulin ratio
End stage	4.1 ± 2.6	3.7 ± 1.2	0.662

Baseline, fasted (0 min). End stage, 90–120 min averages or areas under the curves. Systeme International unit conversion factors: E₂ (3.671, pmol/liter); glucose (0.0555, mmol/liter); INS (7.175, pmol/liter); and CPEP (1, μg/liter).