Table 1.

Macroscopic amiloride-sensitive currents and current ratios at −100 mV

	INa, μA	IK/INa	ILi/INa	n
αS589Aβγ	36.0  ±  3.8	0.06  ±  0.01*	0.95  ±  0.05*	40
αS589Cβγ	6.0  ±  0.5*	0.21  ±  0.02*	1.29  ±  0.04	35
αS589Dβγ	1.5  ±  0.1*	0.32  ±  0.02*	1.42  ±  0.04	30
αβS531Aγ	12.1  ±  1.5*	0.01  ±  0.01	1.41  ±  0.11	9
αβγS543A	0.2  ±  0.7*	0.00  ±  0.00	2.20  ±  0.2*	5
wt	27.3  ±  2.5	0.00  ±  0.01	1.47  ±  0.05	43

Amiloride-sensitive currents were measured in solutions containing 120 mM Na⁺, Li⁺, or K⁺ (see Methods). ∗, different from wt (P < 0.01).