Figure 1.

Specificity of LOX reaction with substrates containing one doubly allylic methylene. In this case, the specificity of the LOX reaction solely depends on the direction of the radical rearrangement. [+2] Radical rearrangement indicates that dioxygen is inserted at the second carbon atom in the direction of the methyl terminus of the substrate counted from the site of hydrogen removal. [−2] Indicates an inverse direction of radical rearrangement.