Table 1.
protectivity AROC values for individual proteins separately derived from predictions based either on antigenicity, 1 – modifications or 1 – variability as well as a combined (sum) score for individual proteins
| protein function | protein | antigenicity | modifications | variability | combined |
| attachment/fusion | P11224 | 0,51 | 0,15 | 0,42 | 0,15 |
| attachment/fusion | 2327073 | 0,77 | 0,69 | 0,77 | 0,77 |
| attachment/fusion | 1930067 | 0,83 | 0,51 | 0,64 | 0,65 |
| attachment/fusion | P09592 | 0,66 | 0,77 | 0,57 | 0,74 |
| RNA encapsidation | 13559809 | 0,62 | 0,48 | 0,50 | 0,46 |
| enzyme/secreted cytolysin | P13128 | 0,45 | 0,47 | 0,43 | 0,45 |
| RNA encapsidation | 37724690 | 0,29 | 0,74 | 0,26 | 0,67 |
| toxin/translocation/binary-toxin | Q46221 | 0,42 | 0,28 | 0,10 | 0,11 |
| attachment/capsid | P30129 | 0,77 | 0,35 | 0,07 | 0,29 |
| DNA replication | 138881 | 0,31 | 0,31 | 0,14 | 0,13 |
| toxin | P01558 | 0,41 | 0,49 | 0,29 | 0,41 |
| host evasion/IgG binding | 13622466 | 0,88 | 0,61 | 0,86 | 0,76 |
| attachment/fusion | 116774 | 0,60 | 0,40 | 0,26 | 0,41 |
| enzyme/host evasion | 15644702 | 0,68 | 0,55 | 0,65 | 0,63 |
| enzyme/protease | P10845 | 0,91 | 0,55 | 0,60 | 0,77 |
| attachment/fusion | P03449 | 0,59 | 0,50 | 0,45 | 0,49 |
| transport | P13794 | 0,82 | 0,75 | 0,64 | 0,81 |
| attachment/fusion | P08669 | 0,63 | 0,58 | 0,67 | 0,70 |
| attachment (?) | Q02938 | 0,82 | 0,60 | 0,54 | 0,73 |
| enzyme/protease/tissue invasion | 30260755 | 0,18 | 0,80 | 0,94 | 0,85 |
| unknown function | P13403 | 0,55 | 0,75 | 0,51 | 0,73 |
| unknown function | P13664 | 0,46 | 0,68 | 0,91 | 0,70 |
| unknown function | 42374894 | 0,62 | 0,58 | 0,64 | 0,66 |
| toxin/translocation/binary-toxin | P13423 | 0,59 | 0,62 | 0,22 | 0,56 |
| unknown function | 14162008 | 0,23 | 0,23 | 0,11 | 0,08 |
| attachment/fusion | P59594 | 0,57 | 0,45 | 0,59 | 0,52 |
| transport | P16567 | 0,47 | 0,51 | 0,20 | 0,31 |
| unknown function | 13621499 | 0,35 | 0,30 | 0,65 | 0,36 |
| attachment (?) | 13622014 | 0,27 | 0,46 | 0,16 | 0,39 |
| unknown function | 15675130 | 0,64 | 0,96 | 0,73 | 0,92 |
| unknown function | 13622584 | 0,63 | 0,56 | 0,72 | 0,65 |
| unknown function | 790646 | 0,98 | 0,83 | 0,25 | 0,95 |
| host evasion/resistance to phagocytosis (?) | P26948 | 0,62 | 0,57 | 0,61 | 0,70 |
| unknown function | P21206 | 0,54 | 0,52 | 0,43 | 0,58 |
| enzyme | 153640 | 0,35 | 0,88 | 0,80 | 0,87 |
| transport | 13623184 | 0,55 | 0,70 | 0,65 | 0,69 |
| attachment/fusion | P35253 | 0,56 | 0,45 | 0,27 | 0,38 |
| host evasion/resistance to phagocytosis/toxin | P55128 | 1,00 | 0,40 | 0,54 | 0,73 |
| attachment/fusion | P03524 | 0,54 | 0,73 | 0,65 | 0,73 |
| host evasion/superantigen | P06886 | 0,90 | 0,68 | 0,37 | 0,80 |
| toxin | P0A0L2 | 0,43 | 0,54 | 0,49 | 0,46 |
| host evasion/superantigen | P01552 | 0,34 | 0,59 | 0,38 | 0,53 |
| attachment | 97812 | 0,80 | 0,57 | 0,80 | 0,73 |
| attachment/fusion | P27662 | 0,66 | 0,43 | 0,72 | 0,50 |
| host evasion/resistance to phagocytosis | P12379 | 0,44 | 0,47 | 0,35 | 0,41 |
| host evasion/resistance to phagocytosis | P02977 | 0,32 | 0,37 | 0,25 | 0,33 |
| transport | 13621681 | 0,64 | 0,41 | 0,54 | 0,46 |
| toxin/peptidase/binary-toxin | P15917 | 0,51 | 0,22 | 0,65 | 0,21 |
| attachment/fusion | P33478 | 0,71 | 0,61 | 0,69 | 0,69 |
| unknown function | P19597 | 0,85 | 0,87 | 0,61 | 0,86 |
| attachment/fusion | P07946 | 0,71 | 0,46 | 0,31 | 0,53 |
| attachment/fusion | Q05320 | 0,43 | 0,54 | 0,18 | 0,38 |
| attachment/RNA encapsidation | P03308 | 0,88 | 0,86 | 0,71 | 0,82 |
| attachment/fusion/neuraminidase | O89343 | 0,19 | 0,88 | 0,31 | 0,71 |
| attachment/fusion | P05769 | 0,93 | 0,97 | 0,91 | 0,97 |
| attachment/RNA encapsidation | P08617 | 0,86 | 0,82 | 0,86 | 0,90 |
| attachment/fusion | Q69091 | 0,89 | 0,69 | 0,45 | 0,78 |
| merged (contaminated) | 0,66 | 0,62 | 0,62 | 0,65 | |
| mean non-contaminated | 0,60 | 0,56 | 0,52 | 0,59 | |
| mean contaminated | 0,60 | 0,57 | 0,51 | 0,59 | |
| median non-contaminated | 0,62 | 0,56 | 0,56 | 0,65 | |
| median contaminated | 0,55 | 0,59 | 0,51 | 0,63 |
Proteins highlighted in bold are markedly homologous or identical to sequences used for the training of the PCA19 antigenicity classifier. Values derived from those proteins are denoted as "contaminated". The last five rows compare overall (global) classification performances of concatenated (merged) proteins as well as mean and median values between individual parameters and the combined score. Note that "merged" does not mean averaged and is thus biased by the length of individual proteins.