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. 2007 Oct 30;4:79. doi: 10.1186/1742-4690-4-79

Figure 2.

Figure 2

Amino acid sequence alignment of the lentiviral integrase catalytic core domain (IN CCD). Amino acid sequences were aligned with BioEdit and alignments manually edited to eliminate gaps. FIV-Fca, FIV-Oma, and FIV-Pco refer to feline immunodeficiency viruses from domestic cat, Pallas' cat, and puma, respectively. The FIV-Fca clade is indicated by capital letters. The catalytic triad is marked by the black arrows. Blue arrows show the amino acids reported to confer significant cross-resistance to the major classes of IN strand transfer inhibitors. Small arrows show minor drug resistance mutations. Amino acid numbering refers to HIV-1 IN. The Pol IN CCD sequences aligned were from: immunodeficiency virus type-1 (HIV-1) [PDB: 1BL3C]; simian immunodeficiency virus, host: macaque (SIV-mac) [PDB: 1C6VC]; FIV-Fca: Petaluma (Pet) [REFSEQ: NP_040973.1], San Diego (SD) [Swiss-Prot: :P19028], TM2 [GenBank: AAA43071], BM3070 [GenBank: AAM13444], C36 [GenBank: AAT12494]; FIV-Oma: Oma-3 [GenBank: AAU20798.1]; FIV-Pco: PLV-1695 [GenBank: ABB29307.1] and PLV-14 [GenBank: AAA67168.1]. M2 and M3 are local field isolates of FIV-Fca, clade B (Pistello et al., 1997, sequences being submitted to GenBank).