Figure 3.

The dimer interface and ligand-binding residues. (A) Interacting residues in domain 1. Side chains are shown for residues that interact across the dimer interface in domain 1 (Fig. 2A). The conserved central Val-51 residue is blue, and Glu-34 is red. Salt bridges between residues at the periphery of the interface are dashed lines. (B) Stereoview (40) of the dimer. Side chains and α carbons are shown for residues important in binding to LFA-1 (red and orange) (3, 37), human rhinoviruses 3, 14, 15, 36, and 41 (yellow and orange) (3–5), and P. falciparum (blue) (6). Only single amino acid substitutions that reduced binding 50% or 2 SD below control are shown.