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Sequence of the variable loop between conserved DFG and APE for MIHCK and other kinases discussed in the text. The arrows indicate the residues in MIHCK that were replaced by Ala, Asp, and Glu. The residues that are conserved in all protein kinases, DFG and APE, and the Thr that is conserved in all Ser/Thr kinases residues are in boldface type. Residues that have been shown to be phosphorylated are double underlined. See text for references.
