Figure 5.

Higher magnification of the region of interest in the model of MIHCK catalytic domain with residues of interest marked. The catalytic loop is in yellow and the variable loop is in green. S627 (Ser-627) is the regulatory phosphoserine, and T631 (Thr-631) is the Thr that is conserved in all Ser/Thr kinases. The distances between these and other residues of interest are discussed in the text and, for Thr-631 and the corresponding residue in other kinases whose crystal structures are available, summarized in Table 2. See text for details.