FIG. 1.
CAR mediates infection of CVB3 PD. Replication of CVB3 P, CVB3 M2, CVB3 PD, and CVB3 Bgl/Spe was studied by determination of virus titers (A) and quantification of the virus-induced CPE (B) during three passages in CAR-positive but HS-negative Raji cells. The data show the means ± standard deviation from three experiments. Furthermore, CVB3 PD replication in Raji cells was blocked with CAR antibody (C), and CAR-negative HS negative pgsD-677 cells transfected with CAR became susceptible to CVB3 P and CVB3 PD (D). OD, optical density; lg TCID50, log 50% tissue culture infective dose.