FIG. 2.

Influence of HS pattern on replication of CVB3 variants in CHO cells. CHO cell mutants were infected with the indicated viruses at a MOI of 1. Three virus passages were performed. At the end of the third passage, cells were stained with crystal violet formalin to visualize the virus-induced CPE. Titers of virus were estimated by endpoint titration (A). In addition, virus replication in CHO mutant cells was verified by indirect immunfluorescence of virus-infected cells after infection with CVB3 PD (MOI of 1) at 48 h p.i. (B).