Table 1.

Significant and Suggestive QTLs for Carotid Atherosclerotic Lesions, LDL/VLDL, HDL Cholesterol, and Triglyceride Identified in an Intercross Between B6.apoE^−/− and C3H. ^−/− Mice

Chromosome Marker (cM)	Traits	LOD*	SI (cM)†	Variance (%)‡	P Value	Model of Inheritance
D1Mit45 (58.5)	Lesion	2.9	32–70	5	1.3×10−3	Additive
D5Mit210 (64)	Lesion	3.2	56–72	7	1.2×10−4	Dominant/C3H
D6Mit102 (38.5)	Lesion	3.1	21–60	6	6.9×10−4	Additive
D11Mit36 (47.64)	Lesion	2.4	37–54	5	3.4×10−3	Additive
D12Mit285 (25)	Lesion	4.5	21–28	8	6.0×10−5	Additive
D1Mit270 (92.3)	LDL/VLDL	10.1	79–95	19	<10−5	Dominant/C3H
D3Mit21 (19.2)	LDL/VLDL	2.7	11–28	6	1.6×10−3	Additive
D6Mit243 (30.4)	LDL/VLDL	2.2	25–59	5	4.5×10−3	Additive
D9Mit274 (38)	LDL/VLDL	2.7	35–67	5	2.7×10−3	Dominant/C3H
D12Mit97 (47)	LDL/VLDL	4.6	38–56	8	3.0×10−5	Additive
D1Mit406 (101.2)	HDL	7.2	88–103	13	<10−5	Additive
D2Mit263 (92)	HDL	4.3	87–98	8	4.0×10−5	Dominant/B6
D17Mit244 (55.7)	HDL	3	45–56	5	1.2×10−3	Dominant/B6
D1Mit270 (92.3)	Triglyceride	8.8	85–99	18	<10−5	Dominant/C3H
D2Mit263 (92)	Triglyceride	2.5	89–103	6	2.6×10−3	Dominant/C3H
D5Mit95 (68)	Triglyceride	3.2	65–70	9	3.0×10−5	Additive
D9Mit260 (38)	Triglyceride	2.5	20–65	5	3.2×10−3	Dominant/C3H

^*LOD scores were obtained by dividing the LRS by 4.6. For lesion area: suggestive QTL LOD ≥2.2, significant LOD ≥3.6; for LDL/VLDL: suggestive QTL LOD ≥2.2, significant LOD ≥3.6; for HDL: suggestive QTL LOD ≥2.2, significant LOD ≥3.5; for triglyceride: suggestive QTL LOD ≥2.2, significant LOD ≥3.5.

^†Support interval (SI) was defined as a one-unit drop in LOD score on both sides of the peak marker.

^‡Variance (%) indicates the percentage of the total trait variance, which could be explained by a QTL at this locus.